Juan Manuel Falcón‐Pérez

This study defines the core proteome and contaminants of plasma extracellular vesicles through a meta-analysis of 515 human proteomes, revealing distinct biological sources and functional modules.

This study identifies how a single mutation in the Omicron variant of SARS-CoV-2's ORF3a protein alters its host-cell remodelling effects, shifting from lipid accumulation to preserving Golgi structure.

This study shows astrocytes regulate local protein synthesis in neurons by releasing extracellular vesicles containing Rps6, enhancing synaptic markers.

The paper surveys awareness of extracellular vesicles' translational potential across academia and industry, highlighting growing interest and spin-out efforts in EV-based products.

The paper investigates metabolic and transcriptional changes in microglia after phagocytosis, showing these adaptations sustain their functionality and regenerative properties.

The paper develops and validates a method to measure polyamine levels in cultured cells, showing varying sensitivity for different polyamines.

This study identifies spermidine synthase as a PGC1-regulated secreted protein that mediates paracrine tumor suppression in prostate cancer, highlighting a non-cell autonomous mechanism.