António Jacinto

To Recover or Not to Recover: A Urinary Proteomic Perspective on Severe Acute Kidney Injury

This study evaluates a urinary FABP3/APOA1 ratio as a predictor of renal recovery after severe AKI, showing high accuracy in both discovery and validation cohorts.

CCR4+low-density neutrophils define a novel immunosuppressive subset associated with breast cancer progression and early mortality

The paper identifies a novel immunosuppressive neutrophil subset, CCR4+LDN, associated with breast cancer progression and mortality, and shows its potential as a biomarker and therapeutic target.

Sex-specific control of locomotor behavior by neuronal Arhgef10 in aged Drosophila

This study investigates the age- and sex-specific role of dArhgef10 in locomotor behavior in Drosophila, finding it critical in neuronal function, particularly in aged females.

A role for HDAC3 in regulating histone lactylation and maintaining oocyte chromatin architecture and fertility

The paper identifies HDAC3's role in regulating histone lactylation during Drosophila oogenesis, showing its importance for chromatin architecture and fertility.

Metabolic reprogramming regulates histone lactylation during zebrafish caudal fin regeneration

This study shows that lactate-derived histone lactylation increases during zebrafish caudal fin regeneration, linking metabolic changes to epigenetic regulation of tissue repair.

Neutrophils matter: New clinical insights on their role in the progression of metastatic breast cancer

This study investigates the clinical impact of immunosuppressive low-density neutrophils in metastatic breast cancer, finding they correlate with faster disease progression and reduced survival.

Enhancing HLA-DR in Cytotoxic T Lymphocytes is crucial for the development of efficient adoptive T cell Therapies for Breast Cancer

This study shows that enhancing HLA-DR expression in cytotoxic T lymphocytes improves their anti-tumor activity, suggesting strategies to optimize adoptive T cell therapies for breast cancer.

Dachsous is a key player in epithelial wound closure by modulating cell shape changes and cytoskeleton dynamics

This study identifies Dachsous as essential for epithelial wound closure by modulating cell shape changes and cytoskeleton dynamics in Drosophila embryos.

Zebrafish caudal fin amputation induces a metabolic switch necessary for cell identity transitions and cell cycle re-entry to support blastema formation and bone regeneration

Fin ray branching is defined by TRAP+ osteolytic tubules

The paper identifies TRAP+ osteolytic tubules as critical for defining fin ray branchpoints through bone resorption and mineralization balance.

Depletion of senescent cells improves functional recovery after spinal cord injury

The paper shows that removing senescent cells in mice with spinal cord injury improves functional recovery by enhancing myelin preservation, reducing inflammation, and promoting axonal growth.