Sebastian Schuck

The paper shows ESCRT proteins, specifically Snf7 and Bro1, organize stress-induced ER-Golgi contacts in yeast by forming tubular ER subdomains and recruiting tethering proteins.

The paper uses Dynamic Organellar Maps to study protein localization changes in yeast during ER stress, revealing widespread relocalization and new insights into ER stress responses.

The paper identifies optimal combinations of degrons, auxins, and receptors for rapid protein degradation in budding yeast, showing competitiveness with chemical inhibitors and temperature-sensitive mutants.

The paper identifies two cooperating motifs in Roq1 that modulate Ubr1 activity, enhancing ubiquitination of both folded and misfolded proteins during proteotoxic stress.