PhysiologyEMBO Molecular MedicinePeer-reviewed
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Targeting the canonical ER stress IRE1α/XBP1 pathway counteracts pancreatic cancer-induced skeletal muscle wasting
Aniket S. Joshi, Meiricris Tomaz da Silva, Tuan Anh Vuong…·Ashok Kumar
Muscle-specific XBP1 deletion or IRE1α inhibition with 4μ8C preserves muscle mass and strength in KPC pancreatic cachexia mice, curbing proteolysis, STAT3 signaling and fatty acid oxidation.
9 citations