Tadashi Isa

Adolescent prodromal phenotypes of psychiatric disorders: insights from a novel DISC1-perturbed monkey model

This paper presents a novel monkey model with impaired DISC1 gene to study adolescent prodromal phenotypes of psychiatric disorders, finding altered social behavior and disrupted brain connectivity.

Transient focal inactivation of the primary visual cortex abolishes saccadic inhibition

This study shows that transient inactivation of the primary visual cortex eliminates visually-driven saccadic inhibition, highlighting the dominance of the geniculostriate pathway in this reflex.

State-dependent role of interhemispheric pathway for motor recovery in primates

This study shows that the interhemispheric pathway's role in motor recovery changes from inhibitory to facilitatory in primates after corticospinal tract lesioning, affecting hand movements during early recovery.

Reorganization of corticospinal projections after prominent recovery of finger dexterity from partial spinal cord injury in macaque monkeys

This study examines CST reorganization in macaques after partial spinal cord injury, showing axonal sprouting and re-direction in both rostral and caudal spinal segments contributing to recovery of finger dexterity.

Future spinal reflex is embedded in primary motor cortex output

The paper shows that primary motor cortex encodes future spinal reflexes to coordinate with afferent signals and muscle activity during movement.

Global disinhibition and corticospinal plasticity for drastic recovery after spinal cord injury

This study shows that global disinhibition and corticospinal plasticity enable drastic motor recovery after spinal cord injury in macaques through intensive training and cortical electrical stimulation.

Visuomotor activity associated with conditioned hand movements in premotor cortex of blindsight macaques

The paper investigates visuomotor transformations in blindsight macaques, finding that the dorsal premotor cortex maintains task-related theta-band responses after V1 lesioning, suggesting its role in hand movement control.

The primary motor cortex prospectively computes the spinal reflex

The paper shows the motor cortex drives muscle activity through both direct and trans-afferent pathways, implementing internal models for movement control.

FT-GO: a multiplex fluorescent tyramide signal amplification system for histochemical analysis

FT-GO improves fluorescent histochemical analysis by enhancing signal detection while reducing background noise in mouse and marmoset brains.

Multi-Scale LM/EM Neuronal Imaging from Brain to Synapse with a Tissue Clearing Method, ScaleSF

This paper develops a multi-scale neuronal imaging technique combining light and electron microscopy with a tissue clearing method to study brain-wide connectivity across multiple spatial scales.

Dissecting errors made in response to externally- and internally- driven visual tasks in the common marmosets and humans

The paper analyzes error and successful trials in oculomotor tasks across marmosets and humans, finding similar behavioral patterns and suggesting marmosets as a model for studying human oculomotor behavior.

Difference in context-dependency between orienting and defense-like responses induced by the superior colliculus

The paper investigates context-dependent differences in orienting and defense-like responses mediated by distinct pathways in the superior colliculus using optogenetic activation in mice.