Kazuhiko Seki

Tendon-specific PIEZO1 activation enhances neural drive to muscle during ballistic movement

This study shows that tendon-specific PIEZO1 activation increases neural drive to muscle during high-load ballistic movements, without affecting muscle mass or myogenic gene expression.

Neural populations in the dorsal and ventral cervical spinal cord share temporal dynamics during reach

The paper examines neural population dynamics in the dorsal and ventral cervical spinal cord during reaching, finding shared dynamics across these regions despite differences in single-neuron activity.

Fluid amyloid-β (Aβ) biomarkers reflect early β-sheet-rich Aβ deposition during the preclinical stage in Alzheimer's disease model 5XFAD mice

This study shows fluid amyloid-β biomarkers in 5XFAD mice correlate with β-sheet-rich Aβ deposition during preclinical Alzheimer's disease, with sex differences observed.

Spinal interneuronal populations encode static hindlimb posture in the cat

This study investigates how spinal interneurons encode static hindlimb posture in cats by analyzing neuronal activity during robotic limb positioning.

Hierarchical neuronal processing in primary somatosensory cortex during action observation

The paper investigates neuronal activity in primary somatosensory cortex during action observation and execution, finding hierarchical modulation patterns across cortical areas.

Multi-timescale neural adaptation underlying long-term musculoskeletal reorganization.

This study investigates CNS adaptation to long-term musculoskeletal changes in non-human primates, revealing a two-phase adaptation process with distinct time constants.

Autogenic spinal excitatory circuit ensures skilled hand movements in primates

This study identifies spinal excitatory circuits critical for skilled hand movements in primates, showing pre-determined muscle activation patterns during motor planning.

Protocol for intra-nerve AAV injection and dorsal root potential recording for optogenetic modulation of the peripheral sensory nerve activity

Dynamic and context-dependent modulation of proprioceptive input in primate primary motor cortex

The paper shows that proprioceptive input to primate primary motor cortex is generally gated during movement but specific antagonist muscle signals are preserved to support posture control.

Bidirectional Optogenetic Modulations of Peripheral Sensory Nerve Activity: Induction vs. Suppression through Channelrhodopsin and Halorhodopsin

This study demonstrates optogenetic modulation of peripheral sensory nerve activity in rats, showing induction and suppression of large-diameter afferents using ChR2 and eNpHR3.0.

Establishment of a second-generation transgenic marmoset model of polyglutamine disease recapitulating neurological symptoms and pathology

This paper describes a second-generation transgenic marmoset model of SCA3 that replicates motor impairments and neuropathology, offering a platform for studying disease mechanisms and therapies.

Spinal and cortical premotor control of primate dexterous hand movements

This study investigates the functional differences between direct corticomotoneuronal and indirect corticospinal pathways in primate hand movement control during a precision grip task.

Modulation of somatosensory signal transmission in the primate cuneate nucleus during voluntary hand movement

The paper shows that during voluntary movement, sensory signals are attenuated in the primate cuneate nucleus, suggesting it plays a role in modulating somatosensory transmission.

Distinct sensorimotor feedback loops for dynamic and static control of primate precision grip

The paper investigates distinct neural circuits for dynamic and static control of primate precision grip through coherence analysis between spinal cord, motor cortex, and EMG signals.

Two distinct proprioceptive representations of voluntary movements in primate spinal neurons

The paper records spinal neuron activity in monkeys during voluntary wrist movements and finds two distinct groups with different firing patterns and input-output control, suggesting coordinated proprioceptive representation.