Peter J. Espenshade

In vivo CRISPR screening identifies geranylgeranyl diphosphate as a pancreatic cancer tumor growth dependency

The paper identifies geranylgeranyl diphosphate as essential for pancreatic cancer growth through in vivo CRISPR screening and shows that targeting its synthesis reduces tumor burden.

Identification of substrates for the conserved prolyl hydroxylase Ofd1 using quantitative proteomics in fission yeast

This study identifies new substrates of the prolyl hydroxylase Ofd1 in fission yeast using quantitative proteomics, revealing expanded biological functions beyond its known role in ribosome regulation.