Paul De Koninck

This study characterizes brain maturation in larval zebrafish using brain-wide imaging, revealing changes in functional connectivity, network organization, and cellular activity patterns.

This paper introduces a method to improve STED microscopy by using fluorescence lifetime unmixing and filtering to enhance resolution and accuracy in two-species imaging.

The paper shows functional connectivity gradients in zebrafish brains align with geometric eigenmodes when connectivity is local, but this alignment breaks down with more long-range connections.

This paper introduces STED-FM, a foundation model for STED microscopy that learns robust representations without extensive annotations, improving downstream tasks like classification, segmentation, and image denoising.

This study profiles neural dynamics across species during anaesthesia, finding conserved dynamical changes and linking them to molecular mechanisms.

The paper compares sensorimotor responses in wild-type and GCaMP6s transgenic zebrafish larvae, finding a developmental switch in light and vibration responses but no major difference in response maturation.

The paper investigates the structural and genetic basis of functional brain networks in zebrafish using whole-brain imaging and genetic expression data, revealing similarities to mammalian networks.

This paper introduces a PU learning-based method for detecting and segmenting miniature synaptic calcium transients, showing improved performance over traditional methods in cultured rat neurons.

MICRA-Net is a weakly-supervised neural network that uses a simple classification task to perform segmentation, detection, and enumeration on microscopy images with limited annotated data.

The paper shows that ATP/ADP levels and autophagy interact to regulate neuronal migration by controlling cell pausing and focal adhesion recycling in mice.

The paper uses deep learning to analyze F-actin structures in hippocampal neurons, showing activity-dependent remodeling in dendrites but not axons.

The paper investigates how tubulin conformation and mitochondrial positioning affect anterograde transport along microtubules in vitro and in vivo.

This study identifies netrin-1 as an activity-dependent effector of synaptic plasticity by promoting GluA1-containing AMPAR insertion at hippocampal synapses.