Timothy E. Kennedy

The paper investigates how epigenomic factors like chromatin accessibility and histone modifications affect human oligodendrocyte myelination and age-related vulnerability to injury.

This study shows that dPGA-coated substrates support longer-term mixed glial cultures, enabling repeated isolation of immature oligodendrocyte lineage cells compared to PDL-coated substrates.

This study shows acetylcholine and netrin-1 work together to enable persistent firing in the entorhinal cortex, essential for spatial working memory.

This study investigates white matter injury in Sanfilippo disease using mouse models and human samples, revealing demyelination and specific MRI markers for disease progression.

This study develops a dPGA substrate to improve long-term culture of h-iPSC-derived motor neurons for studying viability, molecular identity, and electrophysiological activity.

The paper shows MS-derived oligodendroglia can myelinate axons and form functional connections in a mouse model, suggesting the differentiation block is due to environmental factors, not intrinsic deficits.

This study shows that UNC5B in oligodendrocytes is essential for maintaining paranodal junction stability and myelin integrity in the mature CNS.

This study identifies distinct pre- and post-synaptic roles of DCC in hippocampal synaptic plasticity and spatial memory in adult mice.

This paper develops a deep learning method to quantify oligodendrocyte ensheathment in vitro, achieving accuracy comparable to human experts and enabling high-throughput analysis.

This study shows that netrin-1 expressed by neurons in the adult brain is critical for spatial memory formation, as its deletion impairs memory without affecting anxiety or grooming behavior.

This study identifies netrin-1 as an activity-dependent effector of synaptic plasticity by promoting GluA1-containing AMPAR insertion at hippocampal synapses.