Lu Liu

The paper develops CTG, a diffusion-based method to improve Hi-C data reliability and reveal structural genomic regulation.

The paper uses single-cell whole genome sequencing to identify low frequency somatic copy number alterations in normal human lymphocytes, finding 7.5% of cells have large-size copy number alterations.

The paper maps somatic mutations and clonal expansions in normal human tissues across nine organs, revealing organ-specific patterns of mutation accumulation and clonal evolution.

This paper introduces SHERRY, a new RNA-seq method that avoids second strand synthesis by using Tn5 transposase to directly fragment and prime RNA/DNA hybrids, improving reproducibility and GC uniformity.