Yanyi Huang

This paper introduces PRISM, a method for high-plex spatial RNA imaging using color intensity barcodes, validated across multiple tissues and showing the role of CAFs in tumor microenvironments.

This study shows serotonin modulates the time window for fear learning by regulating neuronal activity in the ventral hippocampus.

This study identifies Cloche/Npas4l as a pro-regenerative platelet factor in zebrafish heart regeneration, showing its role in regulating cardiomyocyte and endothelial cell proliferation through ligand-receptor interactions.

A fuzzy sequencer improves information efficiency and accuracy in DNA resequencing applications.

The paper introduces IMPACT, a method to enhance spatial proteomics resolution and sensitivity through tissue compression and optimized digestion, demonstrating improved protein detection and anatomical resolution.

This study shows that modulating the MMEJ pathway components RPA and POLQ can reduce large deletions and enhance HDR after CRISPR-Cas9 editing.

The paper introduces SPRINTseq, a spatial transcriptomics method that enables fast, sensitive, and high-resolution data acquisition, revealing cellular and subcellular molecular architecture in Alzheimer's disease.

SHERRY2 is a single-cell RNA sequencing protocol that improves sensitivity and accuracy by eliminating second-strand cDNA synthesis, outperforming existing methods in detecting low-abundance transcripts and specific gene functions.

The paper develops CTG, a diffusion-based method to improve Hi-C data reliability and reveal structural genomic regulation.

This study uses proteomic analysis to show that colostrum from mothers with COVID-19 has increased immune-related proteins and glycosylation, suggesting potential protective benefits against SARS-CoV-2.

The paper uses single-cell whole genome sequencing to identify low frequency somatic copy number alterations in normal human lymphocytes, finding 7.5% of cells have large-size copy number alterations.

The paper maps somatic mutations and clonal expansions in normal human tissues across nine organs, revealing organ-specific patterns of mutation accumulation and clonal evolution.

This paper introduces iMiGseq, a method for ultra-sensitive mtDNA sequencing in oocytes, revealing hidden heterogeneity and deleterious variants in human and mouse samples.

MINERVA enables rapid, high-quality SARS-CoV-2 whole genome sequencing from clinical samples by simplifying library preparation and improving viral enrichment.

This study uses scRNA-seq to analyze yeast ageing, finding increased transcriptional variability and identifying FIT3 as a marker of early heterogeneity.

The paper develops a method to quantify rare genetic variants in human cells using long-read sequencing and shows CRISPR-Cas9 induces nonrandom large deletions and insertions.

The paper introduces GeACT, a genomic database for human mid-gestation fetus cells, linking gene expression to chromatin states and identifying key transcription factors.

This paper introduces SHERRY, a new RNA-seq method that avoids second strand synthesis by using Tn5 transposase to directly fragment and prime RNA/DNA hybrids, improving reproducibility and GC uniformity.

This study compares three droplet-based ultra-high-throughput single-cell RNA-seq systems to identify their distinguishing features and suitable applications.