Jianbin Wang

GEfetch2R downloads and processes scRNA-seq and bulk RNA-seq data from public repositories, converts formats between scRNA-seq objects, and benchmarks conversion tools.

This paper introduces PRISM, a method for high-plex spatial RNA imaging using color intensity barcodes, validated across multiple tissues and showing the role of CAFs in tumor microenvironments.

This study identifies Cloche/Npas4l as a pro-regenerative platelet factor in zebrafish heart regeneration, showing its role in regulating cardiomyocyte and endothelial cell proliferation through ligand-receptor interactions.

A fuzzy sequencer improves information efficiency and accuracy in DNA resequencing applications.

The paper introduces IMPACT, a method to enhance spatial proteomics resolution and sensitivity through tissue compression and optimized digestion, demonstrating improved protein detection and anatomical resolution.

The paper introduces SPRINTseq, a spatial transcriptomics method that enables fast, sensitive, and high-resolution data acquisition, revealing cellular and subcellular molecular architecture in Alzheimer's disease.

The paper introduces ggcoverage, an R package for visualizing and annotating genome coverage from NGS data, offering flexibility and publication-quality plots.

This study shows that endothelial Brg1 regulates Notch signaling in zebrafish heart regeneration by modulating H3K4me3 levels and interacting with Kdm7aa.

SHERRY2 is a single-cell RNA sequencing protocol that improves sensitivity and accuracy by eliminating second-strand cDNA synthesis, outperforming existing methods in detecting low-abundance transcripts and specific gene functions.

This study uses proteomic analysis to show that colostrum from mothers with COVID-19 has increased immune-related proteins and glycosylation, suggesting potential protective benefits against SARS-CoV-2.

The paper uses single-cell whole genome sequencing to identify low frequency somatic copy number alterations in normal human lymphocytes, finding 7.5% of cells have large-size copy number alterations.

The paper maps somatic mutations and clonal expansions in normal human tissues across nine organs, revealing organ-specific patterns of mutation accumulation and clonal evolution.

This paper introduces Kmermaid and Orpheum to enable scRNA-seq analysis in species without reference genomes by detecting cell type-specific sequences without gene annotations.

MINERVA enables rapid, high-quality SARS-CoV-2 whole genome sequencing from clinical samples by simplifying library preparation and improving viral enrichment.

This study uses scRNA-seq to analyze yeast ageing, finding increased transcriptional variability and identifying FIT3 as a marker of early heterogeneity.

This paper introduces SHERRY, a new RNA-seq method that avoids second strand synthesis by using Tn5 transposase to directly fragment and prime RNA/DNA hybrids, improving reproducibility and GC uniformity.

This study compares three droplet-based ultra-high-throughput single-cell RNA-seq systems to identify their distinguishing features and suitable applications.