Author

Xiao Han

Academy of Military Medical SciencesORCID 0000-0002-6467-1802Unclaimed ORCID profile · follow to get notified of new preprints

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Xiao Han7 papers · Chinese Academy of Sciences

Biology Disciplines

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Neuroscience· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Assay:metagenomics· 1 Research Focus:spatial domain detection· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Ailing Li· 1 shared Ailing LiiD· 1 shared Changwei Liu· 1 shared Damien ChuaiD· 1 shared Guanbo XieiD· 1 shared Guangqin LiuiD· 1 shared Haixin ZhaoiD· 1 shared Ho KoiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperNeuroscience

Ailing Li

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3 papers

Recent·Most cited

Microbial colonization establishes stratified radial niches that coordinate host epithelial and immune maturation in the colon

Xiao Han, Jason Xing Kang, Wai Sinn Soh, Levene Wenqian Chua, Hong Sheng Cheng, Damien Chua, William KK WU, Ho Ko, Yusuf Ali, Nguan Soon Tan, Yi Liu, Joseph J.�Y. Sung, Sunny Hei Wong

This study shows microbial colonization creates stratified niches in the colon that coordinate host epithelial and immune maturation through spatial organization.

bioRxiv · Jul 31, 2026 · PreprintMicrobiology

Microglia-derived IL-18 remodels hippocampal plasticity to constrain traumatic fear memory

xiya fang, yining wang, yezhuang shen, Guanbo Xie, Ran Liu, Hong Cai, Qiuying Han, Xin Xu, Kai Wang, Libing Yin, Jinwei Di, Tao Zhou, Ailing Li, Xiao Han, Weihua Li, Teng Li

This study shows that microglia-derived IL-18 reduces traumatic fear memory by restoring synaptic plasticity and modulating engram cell organization in the hippocampus.

bioRxiv · May 7, 2026 · PreprintNeuroscience

Mitochondrial calcium influx-driven bioenergetics in the dopaminergic system selectively enable drug reward

Jun Xiong Gao, Haixin Zhao, Xiao Han, Lingmin Zeng, Guangqin Liu, Xuechen Wei, Changwei Liu, Wenjun Wu, Siqi Chen, Jiayi Chen, Ting Li, Jiye Yin, Tao Zhou, Xuemin Zhang, Ailing Li, , Xin Pan

The paper identifies mitochondrial calcium influx via MCU as a bioenergetic mechanism that selectively enables drug reward and addictive behaviors while sparing natural reward.

bioRxiv · Jun 10, 2025 · PreprintNeuroscience