Sunny Hei Wong

The paper shows dietary protein affects gut microbial phenylalanine metabolism, which contributes to MASLD, and identifies PAGln as a harmful metabolite.

This study shows microbial colonization creates stratified niches in the colon that coordinate host epithelial and immune maturation through spatial organization.

This paper develops a peptide-based fluorescent probe to detect alpha-synuclein aggregates in the gut, showing high accuracy and specificity for early Parkinson's disease diagnosis.

TidyMass2 improves untargeted metabolomics by inferring metabolite origins and analyzing functional modules, increasing biologically interpretable features from 5.8% to 58.8% in pregnancy urine data.

The paper identifies GlcNAc-MurNAc (GM) as a TLR4 agonist derived from gut microbiota that reduces colonic inflammation in mice.

This paper identifies 4-C-3 as an antitumor metabolite derived from cholesterol by gut microbiota, showing its efficacy in CRC models through dual inhibition of EGFR and KRAS.

The paper reanalyzes RNA-seq data from over 800 MASLD livers to identify transcriptomic shifts and risk stratification, revealing molecular switches and immune-related changes associated with disease progression.

This study shows GLP-1R agonism reduces age-related molecular changes in mice, with effects on multiple omic levels and organ-specific rejuvenation.

This study identifies shared and ethnicity-specific HLA associations with ulcerative colitis through trans-ethnic analysis of diverse populations.