Nguan Soon Tan

This study identifies Roseburia hominis-derived 10-hydroxystearic acid as a metabolite that improves metabolic health by restoring hepatic fatty acid metabolism in mice.

The paper shows dietary protein affects gut microbial phenylalanine metabolism, which contributes to MASLD, and identifies PAGln as a harmful metabolite.

This study shows microbial colonization creates stratified niches in the colon that coordinate host epithelial and immune maturation through spatial organization.

The paper develops bioengineered human tonsil organoids (BTOs) to study immune functions, showing they support antigen-specific responses and immune-stromal interactions comparable to native tissues.

MAPA uses large language models to reduce redundancy in pathway analysis and improve biological interpretation of multi-omics data.

The paper reanalyzes RNA-seq data from over 800 MASLD livers to identify transcriptomic shifts and risk stratification, revealing molecular switches and immune-related changes associated with disease progression.

This study shows that PAX4 variants reduce beta cell function and increase diabetes risk by impairing insulin secretion and hormone gene expression in human cells.