This study identifies CD33-PTSD as a prioritized genetic association through multi-omic analyses and suggests 11 compound candidates for experimental validation.

medRxiv · Sep 23, 2026 · PreprintGenetic & Genomic Medicine

An Expectation and Maximization Algorithm for Multivariate Genome-wide Association Studies (EMmvGWAS)

Chin-Sheng Teng, Xuesong Wang, Cheng Liu, Qishan Wang, Yanru Cui, Shizhong Xu

EMmvGWAS improves multivariate GWAS efficiency by using an EM algorithm to reduce computation time while maintaining statistical power.

Genetics · May 30, 2026Peer-reviewedGenomics

Integrating large-scale meta-GWAS and PigGTEx resources to decipher the genetic basis of complex traits in pig.

Zhiting Xu, Qing Lin, Xiaodian Cai, Zhanming Zhong, Jinyan Teng, Bingjie Li, Haonan Zeng, Yahui Gao, Zexi Cai, Xiaoqing Wang, Liangyu Shi, Xue Wang, Yi Wang, Zipeng Zhang, Yu Lin, , Zhe Zhang

The paper performs a multi-breed meta-GWAS in pigs to identify genomic regions associated with complex traits and integrates with PigGTEx to prioritize variant-gene-tissue-trait circuits.

National Science Review · Feb 14, 2025Peer-reviewedGenetics

The first near-complete genome assembly of pig: enabling more accurate genetic research

Caiyun Cao, Jian Miao, Qinqin Xie, Jiabao Sun, Hong Cheng, Zhenyang Zhang, Fen Wu, Shuang Liu, Xiaowei Ye, Zhe Zhang, Qishan Wang, Yuchun Pan, Zhen Wang

This paper presents a near-complete pig genome assembly, improving upon the existing reference by closing gaps and enhancing gene prediction, which supports better genetic research and applications.

bioRxiv · Oct 13, 2024 · PreprintGenomics

A compendium of genetic regulatory effects across pig tissues

Jinyan Teng, Yahui Gao, Hongwei Holly Yin, Zhonghao Bai, Shuli Liu, Haonan Zeng, Lijing Bai, Zexi Cai, Bingru Zhao, Xiujin Li, Zhiting Xu, Qing Lin, Zhangyuan Pan, Wenjing Yang, Xiaoshan Yu, , George E. Liu

The paper presents PigGTEx, a resource linking genetic variants to transcriptomic phenotypes in pigs, showing pigs' similarity to humans in gene regulation and complex traits.

Nature Genetics · Jan 1, 2024Peer-reviewedGenomics

FarmGTEx TWAS-server: an interactive web server for customized TWAS analysis in both human and farm animals

Zhe Zhang, Zitao Chen, Jinyan Teng, Shuli Liu, Qing Lin, Yahui Gao, Zhonghao Bai, Bingjie Li, George E. Liu, Yuchun Pan, Lingzhao Fang, Qishan Wang

The paper introduces a web server for multi-species transcriptome-wide association study (TWAS) analysis, enabling gene expression prediction and trait association in humans and farm animals.

bioRxiv · Feb 3, 2023 · PreprintBioinformatics

PHARP: A pig haplotype reference panel for genotype imputation

Zhen Wang, Zhe Zhang, Zitao Chen, Jiabao Sun, Caiyun Cao, Zhong Xu, Wei Zhao, Hao Sun, Longyu Guo, Qishan Wang, Yuchun Pan

PHARP provides a high-quality pig haplotype reference panel for genotype imputation, enabling improved GWAS and genomic prediction.

Scientific Reports · Jul 25, 2022Peer-reviewedGenomics