Nadia Benaroudj

Host adaptation drives genome evolution and virulence diversification in a bacterial zoonotic pathogen

The paper examines how host adaptation influences genome evolution and virulence in Leptospira interrogans, showing distinct genetic and regulatory changes in rodent- and cattle-associated lineages.

Revisiting oxygen toxicity: evolution and adaptation to superoxide in a SOD-deficient bacterial pathogen

This study investigates how a SOD-deficient bacterial pathogen adapts to superoxide stress through metabolic pathways rather than enzymatic defenses.

Genomic functional architecture predicts ecological adaptation across a highly diverse bacterial phylum

The paper uses genomic data to show how functional genome architecture correlates with ecological traits in Spirochaetes, revealing ancestral features and evolutionary transitions.

In Vivo Dual RNA-Seq uncovers key toxin-like effectors of epithelial barrier disruption and tissue colonization by an extracellular bacterial pathogen

This study uses dual RNA-Seq to identify bacterial effectors that disrupt host cell junctions and enable Leptospira colonization by modulating calcium signaling.