Mathieu Picardeau

Leptospira infection in European hedgehogs (Erinaceus europaeus): occurrence, diversity and associated risk factors in Greater Paris, France.

This study investigates Leptospira infection in hedgehogs in France, finding that 22% of tested individuals were positive, with L. interrogans SG5 and Australis serogroup as prevalent strains, and age and season as significant risk factors.

Core-sheath coupling controls flagellar curvature and motility in Leptospira

This study reveals how core-sheath coupling in Leptospira flagella controls curvature and motility, showing its importance in viscous environments and infection.

Host adaptation drives genome evolution and virulence diversification in a bacterial zoonotic pathogen

The paper examines how host adaptation influences genome evolution and virulence in Leptospira interrogans, showing distinct genetic and regulatory changes in rodent- and cattle-associated lineages.

Free-Living Amoeba act as transient permissive hosts for Leptospira spp.

This study shows free-living amoebae internalize and transiently host both pathogenic and saprophytic Leptospira without replication, contributing to their environmental persistence.

Revisiting oxygen toxicity: evolution and adaptation to superoxide in a SOD-deficient bacterial pathogen

This study investigates how a SOD-deficient bacterial pathogen adapts to superoxide stress through metabolic pathways rather than enzymatic defenses.

Genomic functional architecture predicts ecological adaptation across a highly diverse bacterial phylum

The paper uses genomic data to show how functional genome architecture correlates with ecological traits in Spirochaetes, revealing ancestral features and evolutionary transitions.

In Vivo Dual RNA-Seq uncovers key toxin-like effectors of epithelial barrier disruption and tissue colonization by an extracellular bacterial pathogen

This study uses dual RNA-Seq to identify bacterial effectors that disrupt host cell junctions and enable Leptospira colonization by modulating calcium signaling.

DMEM and EMEM are suitable surrogate media to mimic host environment and expand leptospiral pathogenesis studies using in vitro tools

This paper identifies DMEM and EMEM as better in vitro media for studying leptospiral pathogenesis compared to EMJH and HAN by mimicking host gene expression profiles.

Evolutionary insights into the emergence of virulent Leptospira spirochetes

This study identifies genetic and phenotypic traits associated with virulence in Leptospira by comparing environmental and pathogenic strains.

Histone-organized chromatin in bacteria

This study shows that histones are essential and form chromatin in bacteria, with a unique DNA binding mode compared to archaea and eukaryotes.