Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in Schistosoma mansoni
Vitor Coutinho Carneiro, Isabel Caetano de Abreu da Silva, Murilo Sena Amaral, Adriana S. A. Pereira, Gilbert O. Silveira, David da Silva Pires, Sergio Verjovski‐Almeida, Frank J. Dekker, Dante Rotili, Antonello Mai, Eduardo José Lopes Torres, Dina Robaa, Wolfgang Sippl, Raymond John Pierce, María Teresa Borrello, , Marcelo Rosado Fantappíé
This study shows that inhibiting SmLSD1 with MC3935 causes transcriptional changes and structural damage in Schistosoma mansoni, leading to parasite death.
PLoS neglected tropical diseases · Jul 1, 2020Peer-reviewedMolecular Biology