The paper examines immune cell profiles around islet autoimmunity seroconversion in children with and without type 1 diabetes, finding differences in immune cell ratios that may reflect immune maturation disruptions.

BMJ Open Diabetes Research & Care · May 1, 2026Peer-reviewedImmunology

Spatial patterning of fibroblast TGFβ signaling underlies treatment resistance in rheumatoid arthritis

Kartik Bhamidipati, Alexa B. R. McIntyre, Shideh Kazerounian, Ce Gao, Soon Wei Wong, Miles Tran, Sean A. Prell, Rachel Lau, Vikram Khedgikar, Christopher Altmann, Annabelle Small, Roopa Madhu, Sonia Presti, Ksenia S. Anufrieva, PHILIP E. BLAZAR, , Kevin Wei

Perivascular COMPhi fibrogenic fibroblasts expand in treatment-refractory rheumatoid arthritis synovium, where endothelial Notch signaling patterns fibroblast TGF-beta sensitivity via TGFBR3 regulation and persists despite post-treatment immune cell depletion.

Nature Immunology · Jan 15, 2026Peer-reviewedImmunology✦ In-depth digest

Ancestry Calibration of Polygenic Risk Scores Improves Risk Stratification and Effect Estimation in African American Adults

Luciana B. Vargas, Mariah Meyer, Iain R. Konigsberg, Aastha Kakar, Patrick M. Carry, Yun Li, Alana C Jones, Hemant K. Tiwari, Vinodh Srinivasasainagendra, Nicole D. Armstrong, Eimear E. Kenny, Bogdan Paşaniuc, Marguerite R. Irvin, Michael H. Cho, Maggie A. Stanislawski, , Ethan M. Lange

This study calibrates polygenic risk scores (PRS) for African American adults based on genetic ancestry, improving risk stratification and effect estimation for type 2 diabetes and height.

medRxiv · Jun 18, 2025 · PreprintGenetic & Genomic Medicine