Charles M. Roco

The paper develops COMPASS, a method to assess splicing variant effects across cell types, identifying disease-associated variants and cell type-specific splicing programs.

This paper introduces an improved combinatorial barcoding method for scRNA-seq that significantly increases sensitivity, detecting more transcripts and genes per cell across various sample types.

This study maps the spatial and single-cell transcriptional landscape of human cerebellar development, revealing cell-type-specific gene expression and implications for neurological disorders.

The paper introduces SPLiT-seq, a scalable scRNA-seq method, and applies it to analyze 109,069 cells from a mouse brain, identifying 13 main cell populations and developmental substructures.