Kathleen J. Millen

The paper identifies ependymomas as originating from the pre-neural crest/roof plate lineage using single-cell transcriptomics and lineage tracing.

This study shows that ECM defects in Down syndrome neurodevelopment cause apical cytoarchitecture and mechanical property instability in neural stem cell models.

This paper uses topic modeling to identify developmental states in medulloblastoma subtypes across multiple datasets and technologies.

This study shows the IFIH1-A946T risk variant increases T1D risk in females but not males by enhancing IFN I signaling and altering immune cell profiles in NOD mice.

The paper presents an improved chromosome-scale genome assembly for the African spiny mouse using long Nanopore reads and validates it with RNA-seq data.

This study investigates the effects of neonatal subarachnoid hemorrhage on cerebellar development in mice, finding disruptions in cell density and structure but no significant motor or learning impairments.

This study maps the spatial and single-cell transcriptional landscape of human cerebellar development, revealing cell-type-specific gene expression and implications for neurological disorders.

The paper identifies PI3K and AKT inhibition as effective in suppressing PIK3CA-driven epileptiform activity in a mouse model, offering a potential therapeutic strategy for drug-resistant epilepsy.

This study investigates BMP signalling's role in cerebellar development in chick and human, showing distinct temporal roles in EGL formation and granule neuron production.

This study shows African Spiny mice can repair kidney injury without fibrosis, unlike mice, suggesting evolutionary adaptations for organ regeneration.