This study shows that ANGPTL3 regulates SmarcAL1 translocation to peroxisomes, affecting lipid metabolism and TG storage in response to cell growth states.

Scientific Reports · Feb 11, 2025Peer-reviewedCell Biology

Mct11 deficiency alters hepatic glucose metabolism and energy homeostasis

Alina Ainbinder, Liping Zhao, Patricia Glover, Karen Gelinas-Roa, Victor Rusu, Alycen M. Harney, Eitan Hoch, Amy Deik, Kerry A. Pierce, Kevin H. Bullock, Courtney Dennis, Sarah Jeanfavre, Jesse Krejci, Jinyoung Choi, Anthony Neil Hollenberg, , Suzanne B.R. Jacobs

This study shows that Mct11 deficiency in mice disrupts hepatic glucose and lipid metabolism, mirroring T2D features, and identifies MCT11 as a potential therapeutic target for T2D.

bioRxiv · Sep 8, 2021 · PreprintGenetics

EDEM3 modulates plasma triglyceride level through its regulation of LRP1 expression

Yuxin Xu, Gina Marie Peloso, Taylor Hanta Nagai, Taiji Mizoguchi, Amy Deik, Kevin H. Bullock, Honghuang Lin, Kiran Musunuru, Qiong Yang, Ramachandran Srini Vasan, Robert Edgardo Gerszten, Clary B. Clish, Daniel James Rader, Sekar Kathiresan

The paper identifies a missense variant in EDEM3 associated with lower blood triglyceride levels and shows EDEM3 deficiency increases LRP1 expression, reducing plasma TG through enhanced lipoprotein uptake.

iScience · Jan 1, 2019Peer-reviewedGenetics

netome: a computational framework for metabolite profiling and omics network analysis

Ali Rahnavard, Daniel S. Hitchcock, Julián Ávila-Pacheco, Amy Deik, Courtney Dennis, Sarah Jeanfavre, Kerry A. Pierce, Kevin H. Bullock, Zachary A. Costliow, Clary B. Clish

netome provides tools for analyzing LC-MS metabolomics data, including quality control, peak alignment, and network-based statistical testing.

bioRxiv · Oct 16, 2018 · PreprintBioinformatics