Amy Deik

Ether glycerophospholipid control of peroxisome degradation confers protection from ischemia

This study identifies FAR1 as a key regulator of peroxisome degradation under hypoxia, linking ether lipid metabolism to autophagy and cardioprotection.

Polyamines buffer labile iron to suppress ferroptosis

This study shows polyamines buffer labile iron to suppress ferroptosis by linking polyamine metabolism to iron homeostasis through a genome-wide CRISPR screen and fluorescent reporter.

Intraoperative arteriovenous patient sampling to assess in situ non-small cell lung cancer metabolism

This study uses intraoperative arteriovenous sampling to measure tumor metabolism in NSCLC patients, revealing distinct metabolic profiles between tumor and normal lung tissue.

Ether lipids influence cancer cell fate by modulating iron uptake

This study shows that ether lipids in cancer cells regulate membrane properties to influence iron uptake, ferroptosis, and metastasis, offering a therapeutic target.

Abnormal Lipid Metabolism and Altered Neuronal Support by Astrocytes Lacking Akap11, a Risk Gene for Schizophrenia and Bipolar Disorder

This study identifies AKAP11's role in regulating lipid metabolism and neuronal support in astrocytes, linking its dysfunction to schizophrenia and bipolar disorder risk.

Epigenetic changes, neuronal dysregulation and metabolomic abnormalities in Zmym2 mutant mice, a genetic model of schizophrenia and neurodevelopmental disorders

ANGPTL3 regulates the peroxisomal translocation of SmarcAL1 in response to cell growth states

This study shows that ANGPTL3 regulates SmarcAL1 translocation to peroxisomes, affecting lipid metabolism and TG storage in response to cell growth states.

Biological age is increased by stress and restored upon recovery

This study shows biological age can increase with stress and decrease with recovery, using epigenetic clocks in mice and humans.

Human hematopoietic stem cell vulnerability to ferroptosis

This study identifies ferroptosis as a vulnerability in human hematopoietic stem cells (HSCs) linked to reduced protein synthesis, showing that blocking ferroptosis rescues HSC maintenance.

Mct11 deficiency alters hepatic glucose metabolism and energy homeostasis

This study shows that Mct11 deficiency in mice disrupts hepatic glucose and lipid metabolism, mirroring T2D features, and identifies MCT11 as a potential therapeutic target for T2D.

EDEM3 modulates plasma triglyceride level through its regulation of LRP1 expression

The paper identifies a missense variant in EDEM3 associated with lower blood triglyceride levels and shows EDEM3 deficiency increases LRP1 expression, reducing plasma TG through enhanced lipoprotein uptake.

netome: a computational framework for metabolite profiling and omics network analysis

netome provides tools for analyzing LC-MS metabolomics data, including quality control, peak alignment, and network-based statistical testing.