Marie-Ange Bonnin

The paper identifies transcriptionally distinct muscle nuclei in fetal chicken limb muscles, showing tip and central domain identities and signaling roles in muscle development.

The paper investigates how spatial and mechanical environments influence myonucleus heterogeneity in muscle development, finding that 2D cultures and paralyzed muscles lose regionalized molecular signatures and cellular diversity.

The paper uses single-cell RNA-sequencing to study fibroblast diversity and developmental trajectories in chicken limb connective tissue, showing a shift from positional signaling to lineage diversification.

The paper identifies a fibroblast-to-myoblast conversion driven by BMP signalling at the muscle-tendon interface during limb development.

The paper shows NOTCH inhibition increases TMEM8C expression and myoblast fusion in chicken embryos by releasing HEYL repression on TMEM8C regulatory regions.

This study identifies mechanical and molecular factors influencing tendon differentiation of C3H10T1/2 cells in 2D and 3D cultures, showing that silicone substrates and 3D fibrin environments enhance tendon marker expression.

The paper identifies molecular niches regulated by connective tissue-associated transcription factors through RNA-seq and ChIP-seq in chick limb cells.