Estelle Hirsinger

Regionalisation of muscle nucleus heterogeneity in foetal skeletal muscle

The paper identifies transcriptionally distinct muscle nuclei in fetal chicken limb muscles, showing tip and central domain identities and signaling roles in muscle development.

RIPOR2 promotes multinucleation of melanoma cells downstream of the RAS/ERK oncogenic pathway

This study identifies RIPOR2 as a downstream target of the RAS/ERK pathway that promotes multinucleation in melanoma cells, contributing to aneuploidy and tumor progression.

Limb connective tissue is organized in a continuum of promiscuous fibroblast identities during development

The paper uses single-cell RNA-sequencing to study fibroblast diversity and developmental trajectories in chicken limb connective tissue, showing a shift from positional signaling to lineage diversification.

BMP signalling directs a fibroblast-to-myoblast conversion at the connective tissue/muscle interface to pattern limb muscles

The paper identifies a fibroblast-to-myoblast conversion driven by BMP signalling at the muscle-tendon interface during limb development.

NOTCH inhibition promotes myoblast fusion by releasing HEYL repression on TMEM8C regulatory regions in foetal skeletal muscles

The paper shows NOTCH inhibition increases TMEM8C expression and myoblast fusion in chicken embryos by releasing HEYL repression on TMEM8C regulatory regions.