Mickael Orgeur

Evaluation of the role of whiB6 and kdpDE in the dominant multidrug resistant clone Mycobacterium tuberculosis B0/W148

This study investigates two mutations in M. tuberculosis B0/W148 clone, finding they do not impair growth or virulence but alter transcriptional profiles.

Mesenchymal Osr1+ cells regulate embryonic lymphatic vessel formation

This study identifies mesenchymal Osr1+ cells as regulators of embryonic lymphatic vessel formation by controlling LEC proliferation and migration.

Genome-wide strategies identify molecular niches regulated by connective tissue-associated transcription factors

The paper identifies molecular niches regulated by connective tissue-associated transcription factors through RNA-seq and ChIP-seq in chick limb cells.

In addition to being a marker for muscle connective tissue, Odd skipped-related 2 (OSR2) is expressed in differentiated muscle cells during chick development

Egr1 deficiency induces browning of inguinal subcutaneous white adipose tissue in mice

This study shows that Egr1 deficiency promotes browning of inguinal white adipose tissue in mice by enhancing Ucp1 expression and reducing extracellular matrix genes.

A dual transcript-discovery approach to improve the delimitation of gene features from RNA-seq data in the chicken model

The paper improves gene feature delimitation from RNA-seq data in chickens by combining genome-guided gene prediction and de novo transcriptome assembly, increasing assignment rates by 20%.