Jinzhu Jia

scDIAGRAM: Detecting Chromatin Compartments from Individual Single-Cell Hi-C Matrix without Imputation or Reference Features

scDIAGRAM detects chromatin compartments in single-cell Hi-C data without imputation or reference features, showing accuracy in simulated and real datasets.

Proteome-wide Mendelian Randomization Analysis Identified Potential Drug Targets for Myocardial Infarction

This study uses proteome-wide Mendelian randomization to identify 7 potential drug targets for myocardial infarction, including proteins with existing or developing drugs.

Mendelian randomization analysis with pleiotropy-robust log-linear model for binary outcomes

This paper introduces two novel MR methods for binary outcomes that address pleiotropy and improve statistical power and reduce false positives.

Direct Reconstruction of Gene Regulatory Networks underlying Cellular state Transitions without Pseudo-time Inference

This paper introduces COSLIR, a method to directly reconstruct gene regulatory networks from time-stamped single-cell data without pseudo-time inference, showing good performance on real datasets.