Víctor M. Pérez‐García

Radiopharmaceutical therapy for metastatic prostate cancer: Insights from mechanistic modeling and in silico trials

This paper develops a mechanistic model to simulate [177Lu]Lu-PSMA RPT in mCRPC, using virtual patients to optimize dosing schedules and evaluate efficacy-toxicity trade-offs.

EGFR-Driven Phenotypes Dictate Differential Therapeutic Response to Radiotherapy and Temozolomide in Glioblastoma.

This study shows that EGFRwt/amp and EGFRvIII GBM models respond differently to radiotherapy and temozolomide, suggesting EGFR status could guide personalized treatment.

Radiation necrosis after radiation therapy treatment of brain metastases: A computational approach

The paper develops computational models to explain the differential growth dynamics between radiation necrosis and recurrent brain metastases, using mathematical simulations and clinical data.

Breaking Down Cell-Free DNA Fragmentation: A Markov Model Approach

The paper develops a Markov model called FRIME to simulate cfDNA fragmentation dynamics and validates it against experimental data, revealing physicochemical differences between mitochondrial and genomic cfDNA.

A mesoscopic simulator to uncover heterogeneity and evolutionary dynamics in tumors

This paper introduces a stochastic mesoscopic simulation framework to model tumor heterogeneity and evolutionary dynamics while maintaining low computational costs.