Author

Pilar Sánchez‐Gómez

Instituto de Salud Carlos IIIORCID 0000-0002-0709-4973Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Alexis Casero· 1 shared Ali Vaziri GohariD· 1 shared Alicia Avis-BodasiD· 1 shared Ana RamosiD· 1 shared Ángel Pérez‐NúñeziD· 1 shared Arabela A. GrigorescuiD· 1 shared Aurelio Hernández‐LaíniD· 1 shared Bakhtiar YaminiiD· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperCancer Biology

Alexis Casero

Author profile →

3 papers

Recent·Most cited

EGFR-Driven Phenotypes Dictate Differential Therapeutic Response to Radiotherapy and Temozolomide in Glioblastoma.

María Castelló-Pons, Miguel Perales-Patón, Matteo Italia, Irene Gómez-Soria, Alexis Casero, Juan Belmonte-Beitia, Víctor M. Pérez‐García, Pilar Sanchez-Góméz

This study shows that EGFRwt/amp and EGFRvIII GBM models respond differently to radiotherapy and temozolomide, suggesting EGFR status could guide personalized treatment.

bioRxiv · Nov 22, 2025 · PreprintCancer Biology

Cellular characterization of the peritumoral brain zone of glioblastomas: heterogenous nature and clinical relevance.

Olaya de Dios, Juan Romero, María de los Ángeles Ramírez-González, Beatriz Herranz-Sanchez, Alicia Avis-Bodas, Ana Ramos, Juan Manuel Sepúlveda-Sánchez, Ricardo Gargini, Berta Segura‐Collar, Gabriel Velilla, Bárbara Meléndez, P. González, Luis Jimenez Roldan, Guillermo García-Posadas, Aurelio Hernández‐Laín, , Pilar Sánchez‐Gómez

This study characterizes the heterogeneity of the GBM periphery, showing that non-enhancing areas have neoplastic features and that tumor infiltration correlates with patient sex, age, and resection extent, impacting prognosis.

bioRxiv · Mar 9, 2025 · PreprintCancer Biology

Rational Design and Optimization of a Potent IDO1 Proteolysis Targeting Chimera (PROTAC)

Paige J. Monsen, Prashant V. Bommi, Arabela A. Grigorescu, Kristen L. Lauing, Yingyu Mao, Payton Berardi, Lijie Zhai, Ohiowele Ojo, Manon Penco-Campillo, Taylor Koch, Michael Egozi, Sonam Jha, Sara F. Dunne, Hong Jiang, Guiqin Song, , Gary E. Schiltz

This study optimizes a PROTAC to degrade IDO1 with high potency in GBM cells, showing sustained degradation via the ubiquitin-proteasome system.

Journal of Medicinal Chemistry · Feb 13, 2025Peer-reviewedBiochemistry