PARP1 regulates the genomic ribonucleotide processing activity of TOP1 to prevent the formation of toxic TOP1-DNA adducts and the associated mutations.
Edward James Sarrain, Quan Wang, Angel Caitlin Bondoy, Feng Guo, Qi Cao, Hengyao Niu
This study shows PARP1 prevents TOP1 from causing deletions at STRs by inhibiting TOP1-DNA adduct formation, which could inform therapies for cancers with RNase H2 mutations.
bioRxiv · Apr 21, 2026 · PreprintBiochemistry