Quan Wang

This study quantifies information-processing-like properties of human cortical organoids using a functional phenotyping framework, linking network function to disease-related mutations and pharmacological perturbations.

This study shows PARP1 prevents TOP1 from causing deletions at STRs by inhibiting TOP1-DNA adduct formation, which could inform therapies for cancers with RNase H2 mutations.

This study shows that Cdc13's dual DNA-binding capability coordinates with Ku to protect telomeres, and mutations in this function lead to metabolic reprogramming and increased fitness in yeast.

This study shows that DNA polymerase δ proofreading nuclease inhibits translesion synthesis and promotes recombination during DNA lesion bypass.