Derek Howard

The paper identifies OSMR and SST as molecular markers for human dermal sleeping nociceptors, providing new therapeutic targets for neuropathic pain.

The paper quantifies microglial contamination in Patch-seq datasets and shows its impact on electrophysiological properties of neurons.

LaminaRGeneVis visualizes gene expression across human neocortex layers using harmonized bulk, single-nucleus, and spatial RNA sequencing data.

The paper evaluates deep convolutional neural networks for representing in situ hybridization gene expression images, showing improved gene re-identification and predictive power for schizophrenia diagnosis.

The paper investigates the interaction between pH and the rs12456492 variant in the RIT2-SYT4 locus in the substantia nigra, finding pH-dependent gene expression effects specific to this region.

This study maps the spatial and cell-type distribution of ACE2 in human and mouse brains using transcriptomic data, revealing potential targets for SARS-CoV-2 infection in the central nervous system.

The paper identifies 11 genes consistently differentially expressed in depression-associated studies and highlights sex-specific effects, particularly for MANEA in cerebral cortex regions.

The paper identifies hypometabolic regions in Alzheimer's disease using PET data and links them to transcriptomic changes in a specific donor's brain, highlighting microglia and ribosomal proteins.

The paper identifies genes susceptible to P. gingivalis gingipains and links them to Alzheimer's disease through ribosomal genes, hypothalamus, and cholinergic neurons.

This study identifies brain regions and genes associated with anorexia nervosa using transcriptomic data and genetic variants.