ImmunologyJACC Basic to Translational SciencePeer-reviewed
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Interleukin-1β Drives Disease Progression in Arrhythmogenic Cardiomyopathy
Vinay R. Penna, Junedh Amrute, Morgan Engel…·Stephen P. Chelko
Human arrhythmogenic cardiomyopathy hearts harbor a lesion niche of POSTN fibroblasts and NLRP3+ inflammatory macrophages; IL-1β neutralization in Dsg2-mutant mice reduced fibrosis, dysfunction, and ventricular ectopy.