X Maggs

Cave adaptation drives coordinated transcriptional remodeling across diverse cell types in the brain of a teleost fish

The paper presents a spatial cell atlas comparing surface and cave-dwelling Mexican tetra fish brains, revealing transcriptional changes across cell types linked to cave adaptation.

A comparative brain atlas of Mexican cavefish identifies naturally-occurring changes in cellular composition and gene expression

This study creates a single-cell atlas of Mexican cavefish brains, revealing differences in cell types and gene expression linked to evolved disease resilience.

Novel mechanisms of chemosensory adaptation to the cave environment

The paper shows cavefish have improved olfaction through physiological adaptations, not expanded chemosensory receptors, and demonstrates reduced flow rate in olfactory pits enhances foraging.

A pangenome framework uncovers the role of deletions in repeated evolution of cave-derived traits

The paper identifies recurrent deletions in cavefish genomes linked to adaptive traits, showing their role in repeated evolution through positive selection.

Hybridization Reveals Cell Type-Specific Regulatory Variation Driving Brain Transcriptomic Divergence

The paper investigates how hybridization affects gene expression in brain tissues by identifying cell type-specific regulatory variation in interspecies fish hybrids.

Comparison of Human Melanoma Single Cell Profiles to Evolutionary Medicine Model Xiphophorus Provides Insights In Disease Control

The paper compares single-cell profiles of Xiphophorus melanomas to human melanomas, showing that Xiphophorus melanomas mimic human melanoma cellular heterogeneity.

Astyanax mexicanus surface and cavefish chromosome-scale assemblies for trait variation discovery

This paper presents chromosome-scale assemblies of Astyanax mexicanus surface and cave populations to study genetic basis of adaptation to cave environments.