Erik R. Duboué

The paper compares microglial cell biology between surface and cave populations of Astyanax mexicanus, finding increased microglia numbers and altered lysosomal activity in cavefish.

The paper investigates how a central dopamine circuit evolves in blind cavefish to adapt light-evoked sensorimotor responses, revealing its role in behavioral adaptation through functional and genetic analysis.

This study creates a single-cell atlas of Mexican cavefish brains, revealing differences in cell types and gene expression linked to evolved disease resilience.

The paper identifies genetic regulators of eye degeneration in cavefish using CRISPR screening and functional assays.

The paper investigates DNA damage and cellular stress in short-sleeping Mexican cavefish, finding elevated DNA damage markers and reduced DNA repair responses compared to surface fish.

The paper examines multi-trait evolution in cavefish, finding shared and distinct genetic mechanisms and evidence for pleiotropy or linkage in trait evolution.

The paper uses neural networks to analyze stress-like behaviors in cave and surface-dwelling Astyanax mexicanus, finding differences in freezing, bottom-dwelling, and hyperactivity.

This study identifies the rx3 gene's role in eye development and loss in cavefish Astyanax mexicanus through CRISPR-Cas9 mutagenesis and behavioral analysis.

The paper investigates postprandial sleep in Mexican cavefish and surface fish, finding that larvae exhibit postprandial sleep while adults do not, suggesting its role in energy conservation.

The paper maps structural brain evolution to anatomical modules by analyzing volume and shape variability in cavefish and hybrids.

The paper shows motor asymmetry in larval teleosts is conserved across species and driven by thalamic neurons, with forms dependent on vision and independent of it.

The paper shows that Mexican cavefish maintain functional connectivity in the tectum despite losing retinal input, with changes in the tectum being genetically distinct from eye loss.

This study shows that early life stress in zebrafish affects glucocorticoid signaling during a critical developmental window, leading to long-term anxiety-like behavior and cortisol dysregulation.

The paper identifies a specialized neural circuit in zebrafish that mediates aversive olfactory responses, showing asymmetric roles of the right habenula.

The paper generates brain atlases of surface and cavefish to identify convergent neuroanatomical and functional changes associated with behavioral evolution.

The paper compares the C-start escape response in Mexican cavefish and surface fish, finding evolved differences in response probability and kinematics across populations.

The paper analyzes stress responses in Astyanax larvae, finding reduced stress measures and increased glucocorticoid receptor expression in some cave populations.

The paper generates a brain atlas of surface fish and three cavefish populations, revealing convergent neuroanatomical changes associated with evolved behavioral traits.

The paper demonstrates the successful generation of stable transgenic lines in Astyanax mexicanus using the Tol2 transposase system, enabling the expression of fluorescent markers in specific cell types.

The paper identifies increased Hypocretin/Orexin signaling as a genetic basis for sleep loss in Mexican cavefish compared to surface fish.