Harini Iyer

The paper compares microglial cell biology between surface and cave populations of Astyanax mexicanus, finding increased microglia numbers and altered lysosomal activity in cavefish.

This study creates a single-cell atlas of Mexican cavefish brains, revealing differences in cell types and gene expression linked to evolved disease resilience.

This study shows that repression of Tfeb and Tfe3 is essential for microglia migration and function by regulating lysosomal activity in zebrafish.