Nicolas Rohner

This study identifies a naturally evolved mutation in mc3r that alters energy homeostasis across development in cavefish, contributing to adaptation to nutrient scarcity.

The paper presents a spatial cell atlas comparing surface and cave-dwelling Mexican tetra fish brains, revealing transcriptional changes across cell types linked to cave adaptation.

This study creates a single-cell atlas of Mexican cavefish brains, revealing differences in cell types and gene expression linked to evolved disease resilience.

The paper investigates genetic repeatability in cavefish traits using QTL mapping, finding shared genomic regions for eye loss but less repeatability for sleep and metabolic traits.

The paper identifies recurrent deletions in cavefish genomes linked to adaptive traits, showing their role in repeated evolution through positive selection.

The paper investigates DNA damage and cellular stress in short-sleeping Mexican cavefish, finding elevated DNA damage markers and reduced DNA repair responses compared to surface fish.

The paper compares aging markers between surface and cavefish populations of Astyanax mexicanus, finding that cavefish show less pronounced aging signatures and suggest metabolic shifts, particularly mitochondrial function, contribute to their extended longevity.

This paper establishes bat muscle cell lines and analyzes their transcriptomic and metabolic profiles to study muscle regeneration and flight muscle biology in bats.

This study characterizes the CRY1 R263Q mutation in subterranean animals, showing altered circadian rhythms and gene expression in mice, but no major metabolic defects.

This study investigates reproductive adaptations in Astyanax mexicanus under nutrient limitation, finding cavefish maintain breeding ability under starvation due to increased maternal nutrient deposition and specific gene expression changes.

This study identifies 683 miRNAs in cavefish, revealing their role in regulating development and metabolism through differential expression and pathway involvement.

The paper investigates postprandial sleep in Mexican cavefish and surface fish, finding that larvae exhibit postprandial sleep while adults do not, suggesting its role in energy conservation.

The paper identifies a specific SNP in Cx50 linked to eye loss in cavefish using a hybrid population from a karst window.

This study examines 3D genome organization in livers of cave and surface morphs of Astyanax mexicanus, linking structural changes to metabolic adaptations.

This paper develops a protocol for isolating and culturing primary fibroblasts from frozen bat wing biopsies and establishes stable cell lines for genetic and physiological studies.

This paper presents chromosome-scale assemblies of Astyanax mexicanus surface and cave populations to study genetic basis of adaptation to cave environments.

The paper identifies FATP2 as a conserved target for preventing starvation-induced liver atrophy by reducing fatty acid uptake in cavefish and other species.

The paper introduces next-generation transgenesis tools for zebrafish and other species, including vectors with fluorescent markers and promoters for specific tissue expression.

This study uses metabolomics to compare long- and short-term fasting responses in cave-dwelling and surface-dwelling Mexican tetra, identifying metabolic differences linked to resilience and longevity.

The paper presents a chromosome-level genome of surface fish Astyanax mexicanus and uses it to identify genetic factors contributing to trait evolution in cavefish populations.

The paper identifies cis-regulatory changes in cavefish that contribute to metabolic adaptation by analyzing epigenetic differences between surface and cave populations.

The paper generates a brain atlas of surface fish and three cavefish populations, revealing convergent neuroanatomical changes associated with evolved behavioral traits.

The paper demonstrates the successful generation of stable transgenic lines in Astyanax mexicanus using the Tol2 transposase system, enabling the expression of fluorescent markers in specific cell types.