Joseph I. J. Ellaway

The paper predicts quaternary structures of viral proteins using AlphaFold2 and AlphaFold-Multimer, identifying new insights into vaccinology and protease targets.

The paper expands the AlphaFold Protein Structure Database to include proteome-scale quaternary structures, predicting 1.81M high-confidence protein complexes and revealing conserved structural clusters across domains of life.

FunCLAN categorises protein complex conformations, measures their similarities, and solves the chain equivalence problem using sequence similarity and superposition transformations.

The paper standardizes naming and annotations for macromolecular complexes in the PDB using external resources, improving FAIRness and enabling better research and education.

The paper clusters experimentally determined protein structures to identify conformational states and compares them to AlphaFold2 predictions.

The paper maps promoter interactions in human ILC3s using PCHi-C and links GWAS risk variants to target genes, identifying new autoimmune disease risk genes.

This study identifies ADAM17 as a protease essential for proteolytic maturation of 2{delta} subunits, which enhances calcium currents and is relevant to neuropathic pain.