Romain Lannes

The paper shows that in Drosophila spermatocytes, nucleoli convert into NLBs that serve as platforms for RNA Polymerase II transcription of Y-linked fertility genes.

The paper shows that defective transcription of AAGAG satellite DNA in Drosophila spermatocytes leads to sex-ratio meiotic drive by causing Y chromosome-containing spermatid death.

This study identifies defective splicing of Y-linked gigantic genes in Drosophila hybrids as a cause of male sterility due to intronic divergence between species.

OmniSplice detects non-canonical splicing events from RNA-seq by analyzing reads overlapping annotated exon ends without assuming predefined splice-junction structures, revealing widespread splicing defects in Drosophila and mouse mutants.

The paper shows that co-transcriptional splicing is essential for the transcription of gigantic genes in Drosophila, preventing transcript entanglement and ensuring proper gene expression.