Jaclyn M. Fingerhut

Developmental conversion of the nucleolus into an RNA Polymerase II transcriptional platform in Drosophila spermatocytes

The paper shows that in Drosophila spermatocytes, nucleoli convert into NLBs that serve as platforms for RNA Polymerase II transcription of Y-linked fertility genes.

Defective transcription of AAGAG satellite DNA causes sex-ratio meiotic drive in Drosophila

The paper shows that defective transcription of AAGAG satellite DNA in Drosophila spermatocytes leads to sex-ratio meiotic drive by causing Y chromosome-containing spermatid death.

Defective splicing of Y-chromosome-linked gigantic genes contributes to hybrid male sterility in Drosophila

This study identifies defective splicing of Y-linked gigantic genes in Drosophila hybrids as a cause of male sterility due to intronic divergence between species.

OmniSplice: detection of non-canonical splicing events from RNA-seq

OmniSplice detects non-canonical splicing events from RNA-seq by analyzing reads overlapping annotated exon ends without assuming predefined splice-junction structures, revealing widespread splicing defects in Drosophila and mouse mutants.

Co-transcriptional splicing facilitates transcription of gigantic genes

The paper shows that co-transcriptional splicing is essential for the transcription of gigantic genes in Drosophila, preventing transcript entanglement and ensuring proper gene expression.

Drosophila Males Use 5'-to-3' Phased Biogenesis to Make Stellate-silencing piRNAs that Lack Homology to Maternally Deposited piRNA Guides

The paper shows that Drosophila males produce Su(Ste) piRNAs through 5'-to-3' phased biogenesis triggered by maternally deposited piRNAs, and this process is bypassed when mothers are XXY.

Eukaryotic translation initiation factor eIF4E-5 is required for spermiogenesis in Drosophila melanogaster

This study shows that eIF4E-5 is essential for spermatid cyst polarization, individualization, and male fertility in Drosophila by regulating caspase activity and Soti localization.

Emergent dynamics of adult stem cell lineages from single nucleus and single cell RNA-Seq of Drosophila testes

The paper provides single nucleus and single cell RNA-seq data from Drosophila testes to study spermatogenesis, identifying rare cell types and developmental transitions.

Localized mRNA translation mediates maturation of cytoplasmic cilia in Drosophila spermatogenesis

The paper shows that localized mRNA translation mediated by RNP granules is essential for cytoplasmic cilia formation in Drosophila spermatogenesis.

Satellite DNA-containing gigantic introns in a unique gene expression program during Drosophila spermatogenesis

The paper identifies a unique gene expression program for genes with intron gigantism in Drosophila spermatogenesis, showing that satellite DNA-containing introns are transcribed and regulated by specific RNA-binding proteins.