Yukiko M Yamashita

This study identifies a haploid-specific genome quality control program in spermatids that eliminates damaged nuclei, revealing a non-canonical role for H2Av in maintaining genome integrity during spermatogenesis.

The paper shows that in Drosophila spermatocytes, nucleoli convert into NLBs that serve as platforms for RNA Polymerase II transcription of Y-linked fertility genes.

The paper shows that defective transcription of AAGAG satellite DNA in Drosophila spermatocytes leads to sex-ratio meiotic drive by causing Y chromosome-containing spermatid death.

The paper shows how Drosophila male germline stem cells maintain potency through inherited mRNAs and niche signals that define distinct identities.

This study identifies defective splicing of Y-linked gigantic genes in Drosophila hybrids as a cause of male sterility due to intronic divergence between species.

This study identifies how the meiotic driver Stellate in D. melanogaster impairs sperm development by delaying nuclear envelope remodeling and disrupting dense complex formation.

This study identifies distinct satellite DNA sequences in core and germline-restricted chromosomes of Bradysia coprophila, revealing cytological evidence for two previously undistinguished L chromosomes.

OmniSplice detects non-canonical splicing events from RNA-seq by analyzing reads overlapping annotated exon ends without assuming predefined splice-junction structures, revealing widespread splicing defects in Drosophila and mouse mutants.

The paper shows insulin signaling represses R2 retrotransposon expression, which is necessary for rDNA copy number maintenance in Drosophila germline stem cells.

The paper identifies a self-restraining sex chromosome driver in D. melanogaster that prevents population extinction by asymmetric segregation during meiosis.

The paper shows that co-transcriptional splicing is essential for the transcription of gigantic genes in Drosophila, preventing transcript entanglement and ensuring proper gene expression.

The paper identifies Indra as a negative regulator of rDNA copy number expansion in Drosophila by repressing RNA polymerase II-mediated rDNA transcription, which facilitates rDNA magnification through retrotransposon activity.

The paper shows that Drosophila males produce Su(Ste) piRNAs through 5'-to-3' phased biogenesis triggered by maternally deposited piRNAs, and this process is bypassed when mothers are XXY.

This study uses advanced microscopy and computational tools to analyze fusome structure and inheritance in insect gametogenesis, revealing sex-specific differences in topology and function.

The paper provides single nucleus and single cell RNA-seq data from Drosophila testes to study spermatogenesis, identifying rare cell types and developmental transitions.

The paper identifies Y-linked protamine-like genes as meiotic drivers in Drosophila by showing they cause nuclear decompaction and biased demise of X-bearing sperm through dominant-negative effects.

The paper investigates ribosomal DNA instability as a driver of karyotype evolution in Drosophila melanogaster by analyzing a strain with X chromosome rDNA loss and Y chromosome truncation.

The paper shows non-random sister chromatid segregation maintains rDNA copy number in Drosophila germline stem cells, contributing to germline immortality.

This study shows that me31B prevents excessive dedifferentiation of spermatogonia into germline stem cells in Drosophila, maintaining stem cell homeostasis by regulating nos.

The paper identifies Alms1a as a regulator of centrosome duplication in asymmetrically dividing Drosophila stem cells and shows its specific requirement in this process.

The paper shows that localized mRNA translation mediated by RNP granules is essential for cytoplasmic cilia formation in Drosophila spermatogenesis.

The paper shows that Klp10A mediates Piwi shuttling between nucleus and nuage during mitosis, linking nuclear and cytoplasmic piRNA silencing arms.

This study characterizes nucleolar dominance in Drosophila melanogaster by analyzing rDNA locus activity during development using SNPs and chromosomal variations.

The paper identifies a unique gene expression program for genes with intron gigantism in Drosophila spermatogenesis, showing that satellite DNA-containing introns are transcribed and regulated by specific RNA-binding proteins.

The paper shows that chromocenter formation in Drosophila depends on interactions between satellite DNA-binding proteins D1 and Prod, which package chromosomes into a single nucleus.

This study shows that rDNA copy number decreases with age in Drosophila male germline stem cells and is heritable but recoverable.

This paper shows Hmr and Lhr are needed for sister chromatid detachment during anaphase, not centromere function, in Drosophila melanogaster.

The paper shows that interconnected germ cells in Drosophila testis die together when exposed to DNA damage, suggesting that connectivity enhances sensitivity to DNA damage.