LENS decodes musculoskeletal pain intensity from sEMG, showing strong generalization to chronic pain cohorts and revealing a conserved pain signature masked by motor variability.

bioRxiv · Sep 14, 2026 · PreprintNeuroscience

Systemic immune dysregulation in hypertensive disorders of pregnancy persists years after delivery

Maximilian Sabayev, Edward A. Ganio, Ina Annelies Stelzer, Sato Masaki, Amélie I. F. Cambriel, Thomas A. Bonham, Zala Nikita Juvan, Maïgane Diop, Purnima Iyer, Oshra Sedan, Nima Aghaeepour, Martin S. Angst, Gary Michael Shaw, David K. Stevenson, Marcia L. Stefanick, , Dorien Feyaerts

This study identifies persistent immune dysregulation in women with hypertensive disorders of pregnancy years after delivery, linked to increased cardiovascular disease risk.

Frontiers in Immunology · Feb 5, 2026Peer-reviewedImmunology

An immune signature of postoperative cognitive decline in elderly patients

Franck Verdonk, Amélie I. F. Cambriel, Julien Jacques Hedou, Edward A. Ganio, Grégoire Bellan, Dyani Kalea Gaudilliere, Jakob F. Einhaus, Maximilian Sabayev, Ina Annelies Stelzer, Dorien Feyaerts, Adam T. Bonham, Kazuo Ando, Benjamin Choisy, David R. Drover, Boris Dov Heifets, , Brice L Gaudilliere

This study identifies an immune signature predicting postoperative cognitive decline using single-cell and plasma proteomic data from elderly patients.

bioRxiv · Mar 2, 2024 · PreprintNeuroscience

Phenotyping aldehyde metabolism in humans uncovers novel genetic mutations in aldehyde dehydrogenase 2

Joseph R. White, Freeborn Rwere, Xiaocong Zeng, Leslie S McNeil, Kevin Zhou, Martin S. Angst, Che‐Hong Chen, Daria Mochly‐Rosen, Eric Richard Gross

The paper develops a method to phenotype ALDH2 genetic differences in humans and identifies novel mutations causing inefficient acetaldehyde metabolism after alcohol consumption.

medRxiv · Jun 26, 2020 · PreprintGenetic & Genomic Medicine

Changes in pregnancy-related serum biomarkers early in gestation are associated with later development of preeclampsia

Shiying Hao, Jin You, Lin Chen, Hui Fen Zhao, Yujuan Huang, Le Zheng, Lü Tian, Ivana Marić, Xin Liu, Tian Li, Katherine Bianco, Virginia D. Winn, Nima Aghaeepour, Brice L Gaudilliere, Martin S. Angst, , Xuefeng B. Ling

This study identifies changes in pregnancy-related serum biomarkers early in gestation as indicators of later preeclampsia development, validated in both human and mouse models.

PLoS ONE · Mar 3, 2020Peer-reviewedMolecular Biology

Integration of Mechanistic Immunological Knowledge into a Machine Learning Pipeline Increases Predictive Power

Anthony Culos, Amy S. Tsai, Natalie Stanley, Martin Becker, Mohammad Sajjad Ghaemi, David R. McIlwain, Ramin Fallahzadeh, Athena Tanada, Huda Nassar, Edward A. Ganio, Laura S. Peterson, Xiaoyuan Han, Ina Annelies Stelzer, Kazuo Ando, Dyani Kalea Gaudilliere, , Nima Aghaeepour

The paper introduces a machine learning method that integrates immunological knowledge to improve predictive power from mass cytometry data.

bioRxiv · Feb 26, 2020 · PreprintBioinformatics