Madelyn H. Ray

The paper uses single nuclei RNA-sequencing to identify striatal cell types in humans and rhesus macaques and finds molecular changes linked to opioid use disorder.

The paper identifies distinct threat and valence signaling in the rat nucleus accumbens core through single-unit activity recordings during fear discrimination tasks.

The paper shows that two VP neuron populations signal relative threat by decreasing firing with increasing shock probability, with one also signaling reward value.

This study shows that the nucleus accumbens core is essential for scaling fear responses to threat levels and for rapidly distinguishing uncertain threats from safety in rats.