Xiangning Xue

Bayesian rhythmic model for jointly detecting circadian biomarkers and predicting molecular circadian time in human post-mortem brain transcriptome

BayCT detects circadian biomarkers and estimates molecular circadian time in human brain transcriptomes, outperforming existing methods by jointly addressing both tasks.

Comparative transcriptomic rhythms in the mouse and human prefrontal cortex

This study compares circadian transcriptomic rhythms in mouse and human prefrontal cortex subregions, finding conserved signaling with sex-specific phase shifts and species-specific rhythmic transcript identities.

Comprehensive evaluation and practical guideline of gating methods for high-dimensional cytometry data: manual gating, unsupervised clustering, and auto-gating

This study evaluates manual gating, unsupervised clustering, and auto-gating methods for high-dimensional cytometry data using six datasets and provides practical guidelines for selecting appropriate methods.

Sex-specific Regulation of Fentanyl Reward by the Circadian Transcription Factor NPAS2

This study identifies sex-specific roles of NPAS2 in fentanyl reward and addiction mechanisms in mice and humans.

Single nuclei transcriptomics in human and non-human primate striatum implicates neuronal DNA damage and proinflammatory signaling in opioid use disorder

The paper uses single nuclei RNA-sequencing to identify striatal cell types in humans and rhesus macaques and finds molecular changes linked to opioid use disorder.

Sexually dimorphic mechanisms of VGLUT-mediated protection from dopaminergic neurodegeneration

This study identifies VGLUT-mediated mechanisms protecting DA neurons from PD-related degeneration, revealing sex-specific effects and transcriptional regulators.

Differential Effects of Cocaine and Morphine on the Diurnal Regulation of the Mouse Nucleus Accumbens Proteome

This study examines how cocaine and morphine affect diurnal proteome rhythms in the mouse nucleus accumbens, revealing distinct pathway alterations.

Circadian rhythm disruptions associated with opioid use disorder in the synaptic proteomes of the human dorsolateral prefrontal cortex and nucleus accumbens

The paper identifies synaptic protein alterations and circadian rhythm disruptions in brain regions associated with opioid use disorder using proteomics.

Molecular rhythm alterations in prefrontal cortex and nucleus accumbens associated with opioid use disorder

The paper investigates molecular rhythm alterations in the prefrontal cortex and nucleus accumbens of individuals with opioid use disorder, finding distinct rhythmic transcript patterns and associations with sleep and neurotransmitter systems.

Transcriptional alterations in opioid use disorder reveal an interplay between neuroinflammation and synaptic remodeling

This study identifies transcriptional changes in opioid use disorder brains, linking neuroinflammation and synaptic remodeling through RNA-seq and integrative analyses.