Gli2 Facilitates Tumor Immune Evasion and Immunotherapeutic Resistance by Coordinating Wnt Ligand and Prostaglandin Signaling
Nicholas C. DeVito, Y‐Van Nguyen, Michael Sturdivant, Michael P. Plebanek, Kaylee A. Villarreal, Nagendra Sastry Yarla, Vaibhav Jain, Michael Aksu, Georgia Marie Beasley, Balamayooran Theivanthiran, Brent Allen Hanks
This paper identifies Gli2 as a key driver of immune evasion and immunotherapy resistance in tumors through Wnt and prostaglandin signaling, offering a therapeutic target for combination immunotherapies.
Cancer Research · Feb 19, 2025Peer-reviewedCancer Biology