Michael Aksu

Multi-region spatial transcriptomics reveals region specific differences in response to amyloid beta (Aβ) plaque induced changes in Alzheimer's Disease (AD)

This study uses multi-region spatial transcriptomics to identify region-specific transcriptional responses to Aβ plaques in AD, revealing differences in neuronal vulnerability and molecular pathways.

Gli2 Facilitates Tumor Immune Evasion and Immunotherapeutic Resistance by Coordinating Wnt Ligand and Prostaglandin Signaling

This paper identifies Gli2 as a key driver of immune evasion and immunotherapy resistance in tumors through Wnt and prostaglandin signaling, offering a therapeutic target for combination immunotherapies.

A neurovascular progenitor sits at the nexus of glioblastoma lineage trajectories

This study identifies a neurovascular progenitor cell type in glioblastoma that links distinct malignant lineages and influences tumor composition and survival.