Author
European Bioinformatics InstituteORCID 0000-0001-8772-6776Unclaimed ORCID profile · follow to get notified of new preprints
7 papers
Recent·Most cited
Jakob Gierten, Bettina Welz, Tomas W. Fitzgerald, Thomas Thumberger, Rashi Agarwal, Oliver Hummel, Adrien Léger, Philipp Weber, Kiyoshi Naruse, David Hassel, Norbert Hübner, Ewan Birney, Joachim Wittbrodt
The paper maps and validates key genetic loci influencing heart rate and function in fish, identifying potential targets for cardiac disease treatment.
Nature Communications · Apr 30, 2025Peer-reviewedGenetics
Tomas W. Fitzgerald, Ian Brettell, Adrien Léger, Nadeshda Wolf, Natalja Kusminski, Jack Monahan, Carl Barton, Cathrin Herder, Narendar Aadepu, Jakob Gierten, Clara Becker, Omar T. Hammouda, Eva Hasel, Colin Q. Lischik, Katharina Lust, , Felix Loosli
The paper introduces the Medaka Inbred Kiyosu-Karlsruhe (MIKK) panel, a vertebrate genetic resource for genotype-to-phenotype studies, enabling controlled experiments on complex traits.
Genome biology · Feb 21, 2022Peer-reviewedGenomics
Adrien Léger, Ian Brettell, Jack Monahan, Carl Barton, Nadeshda Wolf, Natalja Kusminski, Cathrin Herder, Narendar Aadepu, Clara Becker, Jakob Gierten, Omar T. Hammouda, Eva Hasel, Colin Q. Lischik, Katharina Lust, Natalia Sokolova, , Tomas W. Fitzgerald
The paper analyzes genomic and epigenomic variation in the MIKK panel using long-read sequencing and pan-genome graphs, revealing novel structural variants and methylation patterns.
Genome biology · Feb 21, 2022Peer-reviewedGenomics
René Snajder, Adrien Léger, Oliver Stegle, Marc Jan Bonder
pycoMeth provides a toolbox for differential methylation analysis of long-read ONT sequencing data, offering improved efficiency and performance over existing methods.
bioRxiv · Feb 16, 2022 · PreprintBioinformatics
Camilla Ugolini, Logan Mulroney, Adrien Léger, Matteo Castelli, Elena Criscuolo, Maia Kavanagh Williamson, Andrew D. Davidson, Abdulaziz Almuqrin, Roberto Giambruno, Miten Jain, Gianmaria Frigè, Hugh E. Olsen, George Tzertzinis, Ira Schildkraut, Madalee G. Wulf, , Tommaso Leonardi
This study introduces NRCeq, a method to identify capped full-length SARS-CoV-2 transcripts, revealing new insights into sgRNA structure and expression.
Nucleic Acids Research · Feb 16, 2022Peer-reviewedGenomics
Adrien Léger, Paulo Amaral, Luca Pandolfini, Charlotte Capitanchik, Federica Capraro, Valentina Miano, Valentina Migliori, Patrick Toolan-Kerr, Theodora C. Sideri, Anton James Enright, Konstantinos Tzelepis, Folkert Jacobus van Werven, Nicholas M. Luscombe, Isaia Barbieri, Jernej Ule, , Tony Kouzarides
The paper introduces Nanocompore, a method to detect RNA modifications using Nanopore direct RNA sequencing, validated on human polyA+ RNAs and non-coding RNAs.
Nature Communications · Dec 10, 2021Peer-reviewedGenomics
Josie Gleeson, Adrien Léger, Yair D. J. Prawer, Tracy A. Lane, Paul J. Harrison, Wilfried Haerty, Michael B. Clark
This study uses nanopore direct RNA sequencing to accurately detect differential gene and isoform expression between human cell populations during differentiation.
Nucleic Acids Research · Oct 27, 2021Peer-reviewedGenomics