Joseph A. Waldron

Codon-dependent regulation of mRNA translation and stability by ZC3H7A and ZC3H7B RNA-binding proteins

This study identifies ZC3H7A and ZC3H7B as RNA-binding proteins that regulate mRNA stability and translation by targeting non-optimal A/U3 codons.

The differential mechanisms of eIF4A1-mediated translational activation instructed by distinct RNA features

This study identifies how eIF4A1 differentially activates translation based on mRNA features, revealing distinct mechanisms for mRNA selection and inhibition by eFT226 and hippuristanol.

Increased mRNA translation delays lung adenocarcinoma initiation and exposes a therapeutic vulnerability to MEK inhibitors

This study shows that increased mRNA translation delays lung adenocarcinoma initiation and creates a vulnerability to MEK inhibitors in KRAS-driven tumors.

Optimisation of sample preparation from primary mouse tissue to maintain RNA integrity for methods examining translational control

The paper optimizes sample preparation from primary mouse tissue to maintain RNA integrity for translatome analysis techniques like polysome and ribosome profiling.

Purine-rich RNA sequences in the 5'UTR site-specifically regulate eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation

The paper identifies AG-rich RNA sequences in 5'UTRs that regulate eIF4A1 multimerisation to enhance translation of oncogenic mRNAs.