Purine-rich RNA sequences in the 5'UTR site-specifically regulate eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation
Tobias Schmidt, Adrianna Dąbrowska, Joseph A. Waldron, Kelly Hodge, Grigorios Koulouras, Mads Gabrielsen, June Munro, David C. Tack, Gemma Harris, Ewan James McGhee, David J. Scott, Leo M. Carlin, Danny T. C. Huang, John P. C. Le Quesne, Sara R. Zanivan, , Martin Bushell
The paper identifies AG-rich RNA sequences in 5'UTRs that regulate eIF4A1 multimerisation to enhance translation of oncogenic mRNAs.
bioRxiv · Aug 8, 2022 · PreprintMolecular Biology